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PEGylated nanoparticle albumin-bound steroidal ginsenoside derivatives ameliorate SARS-CoV-2-mediated hyper-inflammatory responses by Hee Ho Park; Hyelim Kim; Han Sol Lee; Eun U Seo; Ji-Eun Kim; Jee-Hyun Lee; Yong-Hyeon Mun; So-Yeol Yoo; Jiseon An; Mi-Young Yun; Nae-Won Kang; Dae-Duk Kim; Dong Hee Na; Kyung Soo Hong; Jong Geol Jang; June Hong Ahn; Jong-Sup Bae; Gyu Yong Song; Jae-Young Lee; Hong Nam Kim; Wonhwa Lee is a Engineering article available to read on EtoBox.
What is PEGylated nanoparticle albumin-bound steroidal ginsenoside derivatives ameliorate SARS-CoV-2-mediated hyper-inflammatory responses about?
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on a global scale urges prompt and effective countermeasures. Recently, a study has reported that coronavirus disease-19 (COVID-19), the disease caused by SARS-CoV-2 infection, is associated with a decrease in albumin level, an increase in NETosis, blood coagulation, and cytokine level. Here, we present drug-loaded albumin nanoparticles as a therapeutic agent to resolve the clinical outcomes observed in severe SARS-CoV-2 patients. PEGylated nanoparticle albumin-bound (PNAB) was used to promote prolonged bioactivity of steroidal ginsenoside saponins, PNAB-Rg6 and PNAB-Rgx365. Our data indicate that the application of PNAB-steroidal ginsenoside can effectively reduce histone H4 and NETosis-related factors in the plasma, and alleviate SREBP2-mediated systemic inflammation in the PBMCs of SARS-CoV-2 ICU patients. The engineered blood vessel model confirmed that these drugs are effective in suppressing blood clot formation and vascular inflammation. Moreover, the animal model experiment showed that these drugs are effective in promoting the survival rate by alleviating tissue damage and cytokine storm. Alto
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- Author
- Hee Ho Park; Hyelim Kim; Han Sol Lee; Eun U Seo; Ji-Eun Kim; Jee-Hyun Lee; Yong-Hyeon Mun; So-Yeol Yoo; Jiseon An; Mi-Young Yun; Nae-Won Kang; Dae-Duk Kim; Dong Hee Na; Kyung Soo Hong; Jong Geol Jang; June Hong Ahn; Jong-Sup Bae; Gyu Yong Song; Jae-Young Lee; Hong Nam Kim; Wonhwa Lee
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Engineering (Physical Sciences)