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What is Visible Light C−N Cross-Coupling in Flow about?

The article presents a visible light-mediated flow process for C−N cross-coupling of (hetero)aryl halides with amines using a photoredox/nickel dual catalyst system, significantly improving substrate scope and reducing reaction times to 10-100 minutes. The method allows for easy scale-up, demonstrated by the synthesis of tetracaine with a high yield of 84% on a 10 mmol scale. This approach offers advantages over traditional batch methods, including higher yields and shorter reaction times for various aryl b

Author

kacaires

Language

EN