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Salivary matrix metalloproteinase (MMP-8) levels and gelatinase (MMP-9) activities in patients with type 2 diabetes mellitus by Hanna-Leena Collin; Timo Sorsa; Jukka H. Meurman; Leo Niskanen; Tuula Salo; Hanne Rönkä; Yrjö T. Konttinen; Anna-Maija Koivisto; Matti Uusitupa is a Dentistry article available to read on EtoBox.

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We studied the salivary levels and activities of the matrix metalloproteinases (MMP) -8 and -9 in 45 type 2 diabetic patients and 77 control subjects. The patients' mean glycosylated haemoglobin (HbA1c) was 8.7%, indicating an unsatisfactory metabolic control of the disease. The MMP levels were further related to the clinical and microbiological periodontal findings as well as to salivary flow rate and other factors. The salivary flow rate, albumin and amylase concentrations were similar in type 2 diabetic patients to those in the control group. The mean gingival and periodontal pocket indexes were higher in the diabetes group. The number of potential periodontopathogenic bacteria was lower, however, in the diabetic than in the control group. Zymography and immunoblotting revealed that the major MMPs in the type 2 diabetic patients' saliva were MMP-8 and MMP-9. Salivary MMP levels and activities in type 2 diabetic patients were in general similar to those in the control group. However, the correlation coefficients using multiple regression analysis revealed that gingival bleeding, pocket depths and HbA1c were associated with increased MMP-8 levels which, in turn, were negatively pr

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Author

Hanna-Leena Collin; Timo Sorsa; Jukka H. Meurman; Leo Niskanen; Tuula Salo; Hanne Rönkä; Yrjö T. Konttinen; Anna-Maija Koivisto; Matti Uusitupa

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3484)

Published

2000

Language

EN

Field

Dentistry (Health Sciences)