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Varying populations of CD59-negative, partly positive, and normally positive blood cells in different cell lineages in peripheral blood of paroxysmal nocturnal hemoglobinuria patients by Seitoku Fujioka; Teruo Yamada is a Medicine article available to read on EtoBox.

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CD59-antigen expression on the surface membranes of erythrocytes, granulocytes, monocytes, lymphocytes, and platelets was determined by flow cytometry in 34 healthy controls and 17 patients with paroxysmal nocturnal hemoglobinuria (PNH). In all PNH patients, CD54negative erythrocytes accounted for >10% of the total erythrocyte population. Two erythrocyte populations (CDWnegative and normally positlve or CD5Qnegative and partly positive), three populatlons (CD59-negative, partly positive, and normally positive), and one population (CD54negative) were demonstrated in ten, six, and one patients, respectively. However, CDIQnegative granulocytes did not account for >1 O K of the total granulocytes in two patients, and one of them had only a CD59 normally positive granulocyte population. A particular granulocyte population extended over both CD54 negative and partly positive areas was shown in two patients. Two populations (CD54 negative and normally positive) and one population (CDBQnegatlve) were demonstrated in monocytes and lymphocytes. CDBQnegative lymphocytes accounted for >SO% of the total lymphocytes in only two patients. Three patients had a CD59 normally positive lymphocyte pop

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Author

Seitoku Fujioka; Teruo Yamada

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0361-8609)

Published

1994

Language

EN

ISBN

9782830450200

Field

Medicine (Health Sciences)