Can I read Distribution of pyruvate dehydrogenase dihydrolipoamide acetyltransferase (PDC-E2) and another mitochondrial marker in salivary gland and biliary epithelium from patients with primary biliary cirrhosis on EtoBox?

Distribution of pyruvate dehydrogenase dihydrolipoamide acetyltransferase (PDC-E2) and another mitochondrial marker in salivary gland and biliary epithelium from patients with primary biliary cirrhosis by Ruth E. Joplin; Gerald D. Johnson; John B. Matthews; John Hamburger; J. Gordon Lindsay; Stefan G. Hubscher; Alastair J. Strain; James M. Neuberger is a Medicine article available to read on EtoBox.

What is Distribution of pyruvate dehydrogenase dihydrolipoamide acetyltransferase (PDC-E2) and another mitochondrial marker in salivary gland and biliary epithelium from patients with primary biliary cirrhosis about?

Previous studies in which quantitative immunofluorescenm was used have shown that certain biliary epithelial cells in liver with primary biliary cirrhosis show i n d levels of pyruvate dehydrogenase dihyddipoamide acetyltransferase compared with controls. "his study was designed to determine whether the increase in intensity of pyruvate dehydrogenaee dihydmlipoamide acetyltransferase in biliary epithelial cells is accounted for by an increase in the number of mitochondria in the same cells. A doubleantibody s t u n g technique was used with antibodies specidic for pyruvate dehydrogenase dihydrolipoamide acetyltransferand another mitochondrial inner membrane marker, mcogmwd by the mouse monoclonal antibody MCAlSlA. Distribution of the antigens was studied in sections of liver and salivary gland, an additional site that is frequently involved in primary biliary cirrhosis. Confocal microscopy was used to quantify the intensity of fluorescence resulting from binding of fluomchrome-labeled antibody. In both liver and salivary glands MCA15lA binding was similar in normal and sections with primary biliary cirrhosis and corresponded to the predicted distribution of mitochondria in these h

Who reads Distribution of pyruvate dehydrogenase dihydrolipoamide acetyltransferase (PDC-E2) and another mitochondrial marker in salivary gland and biliary epithelium from patients with primary biliary cirrhosis?

Author

Ruth E. Joplin; Gerald D. Johnson; John B. Matthews; John Hamburger; J. Gordon Lindsay; Stefan G. Hubscher; Alastair J. Strain; James M. Neuberger

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

1994

Language

EN

Field

Medicine (Health Sciences)