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Alcohol, Glucocorticoids, and Inflammation in the Developing Brain by Terrence Deak; Sarah Trapp; Andrew S. Vore; Ashley Lutzke is a Medicine article available to read on EtoBox.

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Pam3Cys-activated TLR2 signaling and imiquimod-activated TLR7 signaling were completely inhibited by 3a,5a-THP (1 mM). By contrast 3a,5a-THP did not inhibit the Poly-IC (TLR3 agonist)-induced increase in CXCL10, suggesting that 3a,5a-THP selectively inhibits signals that function through MyD88, but not TRIF. Likewise, in P rat brain, 3a,5a-THP (15 mg/kg; IP) also inhibited MCP-1 and pIRF7, but had no effect on pIRF3 levels. 3a,5a-THP inhibition of MCP-1 was found throughout the P rat brain in ventral tegmental area, amygdala, hypothalamus and hippocampus. We found a sex difference in baseline MCP-1 (55% higher in male vs. female) and pIRF7 (45% higher in female vs. male). In both sexes, 3a,5a-THP administration reduced the levels of MCP-1 (40% in females; 25% in males) and pIRF7 (55% in males and females). Collectively, the data indicate that 3a,5a-THP modulates TLR signaling pathways resulting in diminished proinflammatory signal activation in immune cells and brain.

Who reads Alcohol, Glucocorticoids, and Inflammation in the Developing Brain?

Author

Terrence Deak; Sarah Trapp; Andrew S. Vore; Ashley Lutzke

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)