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Can I read Kupffer cells and liver metastasis: Optimization and limitation of activation of tumoricidal activity on EtoBox?
Kupffer cells and liver metastasis: Optimization and limitation of activation of tumoricidal activity by Nigel C. Phillips is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Kupffer cells and liver metastasis: Optimization and limitation of activation of tumoricidal activity about?
Kupffer cells, tissue-fixed macrophages located in the sinusoids of the liver, represent the highest concentration of mononuclcar phagocytes in the body. Their ability to act as scavengers of particulate material in the blood has given rise to speculation that they play a role in controlling hepatic metastases derived from blood-borne tumor cells. Circumstantial evidence for such a role has been obtained from animal studies where Kupffer cell function has been compromised or inhibited, and from anecdotal clinical observations. Current evidence suggests that Kupffer cells are capable of nonspccifically climinating some circulating tumor cells from the circulation via phagocytosis. This surveillance mechanism would appear to bc limited in capacity, and subject to a number of external factors. Recent studies have demonstrated that Kupffer cells can be activated to a tumoricidal state via the administration of biological response modificrs such as gamma interferon or muramyl peptidcs. The localization of liposomes within Kupffer cells after systemic administration has provided a considerable stimulus for the efficient targeting of macrophagc-activating compounds to these cells. Such th
Who reads Kupffer cells and liver metastasis: Optimization and limitation of activation of tumoricidal activity?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Nigel C. Phillips
- Publisher
- Springer; Springer-Verlag; Kluwer Academic Publishers; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0167-7659)
- Published
- 1989
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)