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What is Copper-Catalyzed C(sp2)−H Amination about?

This article discusses a copper-catalyzed intermolecular electrophilic amination of benzamides using O-benzoyl hydroxylamines, facilitated by an 8-aminoquinolyl group. The method demonstrates good compatibility with various aryl and heteroaryl amides, achieving selective monoamination under mild conditions. Preliminary mechanistic studies suggest that C−H activation may be the rate-determining step in the reaction.

Author

Sabyasachi

Language

EN