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Can I read Chemical synthesis and immunological evaluation of entirely carbohydrate conjugate Globo H-PS A1† on EtoBox?
Chemical synthesis and immunological evaluation of entirely carbohydrate conjugate Globo H-PS A1† by Ghosh, Samir; Trabbic, Kevin R.; Shi, Mengchao; Nishat, Sharmeen; Eradi, Pradheep; Kleski, Kristopher A.; Andreana, Peter R. is a Chemistry article available to read on EtoBox.
What is Chemical synthesis and immunological evaluation of entirely carbohydrate conjugate Globo H-PS A1† about?
An anticancer, entirely carbohydrate conjugate, Globo H-polysaccharide A1 (Globo H-PS A1), was chemically prepared and immunologically evaluated in C57BL/6 mice. Tumor associated carbohydrate antigen Globo H hexasaccharide was synthesized in an overall 7.8% yield employing a convergent [3 + 3] strategy that revealed an anomeric aminooxy group used for conjugation to oxidized PS A1 __via__ an oxime linkage. Globo H-PS A1, formulated with adjuvants monophosphoryl lipid A and TiterMax® Gold. After immunization an antigen specific immune response was observed in ELISA with anti-Globo H IgG/IgM antibodies. Specificity of the corresponding antibodies was determined by FACS showing cell surface binding to Globo H-positive cancer cell lines MCF-7 and OVCAR-5. The anti-Globo H antibodies also exhibited complement-dependent cellular cytotoxicity against MCF-7 and OVCAR-5 cells.
Who reads Chemical synthesis and immunological evaluation of entirely carbohydrate conjugate Globo H-PS A1†?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Ghosh, Samir; Trabbic, Kevin R.; Shi, Mengchao; Nishat, Sharmeen; Eradi, Pradheep; Kleski, Kristopher A.; Andreana, Peter R.
- Publisher
- The Royal Society of Chemistry; Royal Society of Chemistry; Royal Society of Chemistry (RSC) (ISSN 2041-6520)
- Published
- 2020
- Language
- EN
- Field
- Chemistry (Physical Sciences)