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Front Matter -1 Table of Contents -1 19. Viral Mediated Gene Therapy 1 1. Introduction 1 2. Categories of Viral Vectors 3 2.1 Retroviral Vectors 4 2.2 Lentiviral-Based Retroviral Vectors 7 2.3 Adenoviral Vectors 8 2.4 Adeno-Associated Virus Vectors 12 2.5 Additional Virus Vectors 14 2.5.1 Limited Replication Competent Vectors 15 3. Therapeutic Gene Targeting Using Viral Vectors 16 4. Clinical Applications of Gene Therapy: an Overview 18 4.1 Gene Therapy and Genetic Disorders. 18 4.2 Gene Therapy and Cancer 20 4.3 Gene Therapy for Infectious Disease: The Aids Model 22 5. Summary 23 Biography 24 References 24 Index -1

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