Can I read Thalassemia on EtoBox?

Thalassemia by Caroline Hastings; Joseph C Torkildson; Anurag Kishor Agrawal; Children's Hospital & Research Center Oakland (Oakland, Calif.) is a scholarly article available to read on EtoBox.

What is Thalassemia about?

The thalassemias are a diverse group of genetic diseases characterized by absent or decreased production of normal hemo globin, resulting in a microcytic anemia. The alpha-thalassemias are concentrated in Southeast Asia, Malaysia, and southern China. The beta-thalassemias are seen pri marily in the Mediterranean, Africa, and in Southeast Asia. Due to global migration pat terns, there is an increase in the incidence of thalassemia in North America, primarily because of immigration from Southeast Asia. Like with sickle cell anemia, develop ment of thalassemia is directly related to evolutionary pressure secondary to malaria. Normally, ≥95% of adult hemoglobin found on electrophoresis is hgb A (α 2 β 2 ). Two minor hemoglobins occur: 2-3.5% is hgb A2 (α 2 δ 2 ) and ≤2% is hgb F (α 2 γ 2 ). A mutation affecting globin chain production or deletion of one of the globin chains leads to a decreased production of that chain and an abnormal globin ratio. The globin that is produced in normal amounts is in excess and forms aggregates or inclusions within the red cells. These aggregates become oxidized and damage the cell membrane leading to ineffective erythropoiesis, hemol ysis, or both. The

Author

Caroline Hastings; Joseph C Torkildson; Anurag Kishor Agrawal; Children's Hospital & Research Center Oakland (Oakland, Calif.)

Publisher

Wiley & Sons, Limited, John

Published

2021

Language

EN

ISBN

9781119210757