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pH-responsive chitosan based hydrogels affect the release of dapsone: Design, set-up, and physicochemical characterization by Luíse L. Chaves; Alessandro Silveri; Alexandre C.C. Vieira; Domingos Ferreira; Maria Chiara Cristiano; Donatella Paolino; Luisa Di Marzio; Sofia Costa Lima; Salette Reis; Bruno Sarmento; Christian Celia is a Materials Science article available to read on EtoBox.
What is pH-responsive chitosan based hydrogels affect the release of dapsone: Design, set-up, and physicochemical characterization about?
Dapsone (DAP) is a bactericidal agent used in the treatment of leprosy, caused by Mycobacterium leprae. Despite its therapeutic potential, DAP has low solubility, which results in allow therapeutic index and a high microbial resistance. Recently, new approaches were used to increase the DAP solubility. In particular, the use of interpenetrating polymer network (IPN)-hydrogels based chitosan (CS) for the controlled release of DAP provides some advantages because they can modify their swelling properties and network structures as a response to environmental stimuli. The aim of this study was to synthesize and physicochemically characterize pH-responsive chitosan/polymer hydrogels to control the release of DAP. For this reason, different combination of polymers, such as polyvinyl pyrrolidone, polyethylene glycol and hydroxypropyl methylcellulose, and concentrations of the cross-linking agents (glutaraldehyde) were used and then blended to the CS. The resulting hydrogels were evaluated in terms of physicochemical and swelling properties, rheological analysis and in vitro release of DAP at different pHs (1.2-6.8). Hydrogels were further characterized by Fourier transformed infrared (FT-
Who reads pH-responsive chitosan based hydrogels affect the release of dapsone: Design, set-up, and physicochemical characterization?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Luíse L. Chaves; Alessandro Silveri; Alexandre C.C. Vieira; Domingos Ferreira; Maria Chiara Cristiano; Donatella Paolino; Luisa Di Marzio; Sofia Costa Lima; Salette Reis; Bruno Sarmento; Christian Celia
- Publisher
- Elsevier BV
- Published
- 2019
- Language
- EN
- Field
- Materials Science (Physical Sciences)