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Spatially Fractionated Grid Radiation (SFGRT): A Novel Approach in the Management of Recurrent and Unresectable Soft Tissue Sarcoma by Mohiuddin, M.; Miller, T.; Ronjon, P.; Malik, U. is a Medicine article available to read on EtoBox.

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adjuvant or elective) in 71%. The 2 year and 5 year overall survival (OS) was 72% and 53%, respectively, and the 2 year locoregional control (LRC) rate was 75%. The in-field relapse rate was 3% for primary disease and relapse was significantly lower for patients receiving $ 50 Gy (HR = 0.22, CI: 0.06-0.86). Surgical margins did not affect the local relapse rate. The in-field relapse rate was 11% for RT to the nodes with dose being significant for nodal gross disease (HR = 0.24, CI: 0.07-0.87) and subclinical disease (HR = 0.44, CI: 0.14-1.42). Patients not receiving elective nodal RT had a much higher rate of nodal relapse compared to those who did (HR = 6.03, CI: 1.34-27.10). Conclusions: This study indicates a dose response for subclinical and gross MCC. Doses of 50 Gy for subclinical disease and 55-60 Gy for gross disease are recommended. The draining nodal basin should be treated in all patients.

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Author

Mohiuddin, M.; Miller, T.; Ronjon, P.; Malik, U.

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2009

Language

EN

Field

Medicine (Health Sciences)