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Cross-talk between NF-κB and telomerase in cancer: Implications in therapy by Shrey Madeka; Ekta Khattar is a book available to read on EtoBox.

What is Cross-talk between NF-κB and telomerase in cancer: Implications in therapy about?

Inflammation and replicative immortality are essential for cancer development. Inflammation is primarily driven by the activation of the NF-κB pathway and replicative immortality is mostly achieved by telomerase activation, which maintains telomere length. Interestingly, NF-κB and telomerase activity coexist in cancers and display a very intricate connection. NF-κB regulates the transcription of telomerase catalytic subunit, telomerase reverse transcriptase (TERT) and TERT activates the NF-κB-dependent transcriptional activity. Recently, several novel aspects of this interplay have been discovered. These include uncovering the role of non-canonical NF-κB pathway in transcriptional activation of mutant TERT promoter in cancer cells and the roles of TERT and telomerase RNA component (TERC) in regulating NF-κB transcriptional activity. Here, we present the connections between NF-κB proteins and telomerase in cancer cells along with recent findings, followed by their implications in cancer therapy.

Author

Shrey Madeka; Ekta Khattar

Publisher

Elsevier Science & Technology

Published

2023

Language

EN

ISBN

9780323995221

Subjects

Science, Medical, Biology