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Can I read Oncolytic Peptide Nanomachine Circumvents Chemo Resistance of Renal Cell Carcinoma on EtoBox?
Oncolytic Peptide Nanomachine Circumvents Chemo Resistance of Renal Cell Carcinoma by Jia Yang; Rui Zheng; Muhetaerjiang Mamuti; Da-Yong Hou; Yong-Dan Zhao; Hong-Wei An; Hao Wang; Yuliang Zhao is a Engineering article available to read on EtoBox.
What is Oncolytic Peptide Nanomachine Circumvents Chemo Resistance of Renal Cell Carcinoma about?
Due to intrinsic and acquired chemo/radiotherapy-resistance, renal cell carcinoma shows limited therapeutic response to clinically utilized targeting drugs. Here a tumor-activated oncolytic peptide nanomachine is devised to selectively lysing tumor cell membrane without causing drug resistance. Specifically, in the acidic tumor microenvironment, the oncolytic peptide nanomachine automatically activated through morphologically transformation from nanoparticles to nanofibrils with restoring α-helical conformation, which physically bind to tumor cell membrane with multiple (spatially correlated and time-resolved) interactions and subsequently lyse local cell membrane. The IC 50 of the oncolytic peptide nanomachine is as low as 2.44 μM and it inhibit up to 90% of tumor cells within 2 h with unique bystander killing effect. In vivo, the tumor inhibition rate of the oncolytic peptide nanomachine is 71% without off-target activity and hemolytic activity. These results support that tumorselective oncolytic peptide nanomachine represent a promising alternative approach for multidrug-resistant tumor treatments by inducing cell membrane lysis.
Who reads Oncolytic Peptide Nanomachine Circumvents Chemo Resistance of Renal Cell Carcinoma?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Jia Yang; Rui Zheng; Muhetaerjiang Mamuti; Da-Yong Hou; Yong-Dan Zhao; Hong-Wei An; Hao Wang; Yuliang Zhao
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Engineering (Physical Sciences)