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Effects of Splenic Artery Occlusion on Portal Pressure in Patients with Cirrhosis and Portal Hypertension by Angelo Luca; Roberto Miraglia; Settimo Caruso; Mariapina Milazzo; Bruno Gidelli; Jaime Bosch is a Medicine article available to read on EtoBox.

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The specific contribution of splenic blood inflow to portal hypertension in patients with cirrhosis is still unclear. In this study, we investigated this contribution by assessing the hemodynamic effects of transient splenic artery occlusion. In 15 cirrhotic patients, portal pressure gradient (PPG) was measured just before inserting a transjugular intrahepatic portosystemic shunt (TIPS), in baseline conditions, for 15 minutes after splenic artery occlusion and 5 minutes after recovery. Splenic artery occlusion caused a significant decrease in PPG (range, Ϫ4% to Ϫ38%, median Ϫ20%, P Ͻ 0.001) which promptly returned to baseline values after recovery of the splenic inflow. The decrease in PPG showed a significant correlation with spleen volume (r ϭ 0.70, P Ͻ 0.005), liver volume (r ϭ Ϫ0.63; P Ͻ 0.01), and spleen/liver volume ratio (r ϭ 0.82, P Ͻ 0.001). Seven out of eight patients with a spleen/liver volume ratio greater than 0.5 had a marked decrease in PPG (Ͼ20%), whereas none of patients with a ratio lesser than 0.5 had a marked PPG response. In conclusion, in cirrhotic patients with portal hypertension, splenic artery occlusion causes a significant reduction in portal pressure (PP

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Author

Angelo Luca; Roberto Miraglia; Settimo Caruso; Mariapina Milazzo; Bruno Gidelli; Jaime Bosch

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2006

Language

EN

Field

Medicine (Health Sciences)