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Age‐dependent generation of reactive oxygen species in the skin of live hairless rats exposed to UVA light by H. Yasui; H. Sakurai is a Medicine article available to read on EtoBox.

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**Abstract:** Aging proceeds by highly complicated biochemical processes, in which the involvement of the reactive oxygen species (ROS) and free radicals has been implicated. Although the relationship between UV‐induced photoaging and ROS generation has been proposed, it has been difficult to establish direct proof of the generation of ROS in the skin under UV exposure. Recently, we reported finding endogenously generated ROS in the skin of live mice after UVA light exposure by a method of __in vivo__ chemiluminescent detection, in which superoxide anion radical (^·^O~2~^–^) and singlet oxygen species (^1^O~2~) are contributed. In light of the results, we tried to understand the age‐dependent changes in ROS generation in the skin of hairless rats under UVA exposure. Chemiluminescent levels due to ROS in the untreated and UVA‐exposed skin decreased age dependently, and the signal intensities in old rats were significantly lower than those in young rats. However, the ratios of chemiluminescent intensities in the UVA‐exposed skin to those in the untreated skin were significantly enhanced in an age‐dependent manner. These results suggest that the antioxidative ability against ROS gener

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Author

H. Yasui; H. Sakurai

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0906-6705)

Published

2003

Language

EN

Field

Medicine (Health Sciences)