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Technetium-99m methoxyisobutylisonitrile chest imaging of small cell lung carcinoma : Relation to patient prognosis and chemotherapy response-a preliminary report by Chia-Hung Kao; Sheng-Ping ChangLai; Poon-Ung Chieng; Tzu-Chen Yen is a Medicine article available to read on EtoBox.

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## Background: The purpose of this preliminary study was to evaluate retrospectively the relation between chemotherapy response and survival time, using technetium-99m methoxyisobutylisonitrile (tc-99m mibi) uptake in small cell lung carcinoma (sclc) to detect the expression of multidrug resistance (mdr)-mediated 170-kda p-glycoprotein (pgp). ## Methods: Before the administration of chemotherapy (which consisted of cisplatin 25 mg and etoposide 125 mg every day per 3-day course), 15 male patients (ages 54-64 years) with sclc were enrolled in this study to undergo tc-99m mibi chest imaging, including single photon emission computed tomography (spect) and planar imaging, for qualitative and quantitative assessments of pgp in their sclc. ## Results: In 12 of 15 cases (80%), sclc could be detected by visual interpretation of the tc-99m mibi chest spect images. in 13 of 15 cases (87%), tc-99m mibi chest spect images (either positive spect with good response or negative spect with poor response) correctly predicted chemotherapy response. the correlation between tumor uptake ratios obtained by planar images (total counts in the region of interest [roi] of the tumor divided by total counts

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Author

Chia-Hung Kao; Sheng-Ping ChangLai; Poon-Ung Chieng; Tzu-Chen Yen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

1998

Language

EN

Field

Medicine (Health Sciences)