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Preliminary studies on the immunomodulatory effect of the C3 binding glycoprotein isolated from Cuscuta europea by Spaska Angelova Stanilova; Zhivko Dimitrov Zhelev; Zlatka Georgieva Dobreva is a Immunology and Microbiology article available to read on EtoBox.

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This study investigates the immunomodulatory eect of a C3 binding glycoprotein (C3bgp), isolated from the parasitic plant Cuscuta europea. When BALB/c mice, immunized with sheep red blood cells (SRBC), were given a single intraperitoneal injection of C3bgp a dose-dependent immunostimulation was observed. The stimulation was assessed by an increase in the number of haemolytic plaque forming cells (PFC) and haemaglutination titres. The induction was time dependent in respect to the administration of both the C3bgp and SRBC. When C3bgp was applied 24 h before SRBC at a dose of 30 mg per mouse (1.2 mg/kg), a well expressed immunostimulation was found. It was also found that giving C3bgp to mice, which had previously been treated with the immunosuppressive drug cyclophosphamide (CY), produced an increase in PFC. The immune response was also restored in vitro experiments were performed using human whole blood cultures stimulated with 30 mg/ml C3bgp in the presence or absence of egg albumin (OVA) as antigen for 72 to 168 h. In C3bgp stimulated cultures it was found that after 120 h there was a high expression of the CD 19+ subset of the activation antigen CD25 (IL-2R) as assessed by ̄ow

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Author

Spaska Angelova Stanilova; Zhivko Dimitrov Zhelev; Zlatka Georgieva Dobreva

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0192-0561)

Published

2000

Language

EN

Field

Immunology and Microbiology (Life Sciences)