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Serum Levels of Mannose-binding Lectin and the Risk of Fever in Neutropenia Pediatric Cancer Patients by L.J. Schlapbach; C. Aebi; M. Otth; A. Ridolfi Luethy; K. Leibundgut; A. Hirt; R.A. Ammann is a Medicine article available to read on EtoBox.
What is Serum Levels of Mannose-binding Lectin and the Risk of Fever in Neutropenia Pediatric Cancer Patients about?
## Abstract ## Background Fever in neutropenia (FN) is a frequent complication in pediatric oncology. Deficiency of mannose‐binding lectin (MBL), an important component of innate immunity, is common due to genetic polymorphisms, but its impact on infections in oncologic patients is controversial. This study investigated whether MBL serum levels at cancer diagnosis are associated with the development of FN in pediatric cancer patients. ## Procedure Serum MBL was measured using ELISA. Frequency, duration, and cause of FN were assessed retrospectively. Association with MBL level was analyzed using uni‐ and multivariate Poisson regression taking into account both intensity and duration of chemotherapy. ## Results In 94 children, with a cumulative follow‐up time of 81.7 years, 177 FN episodes were recorded. Patients with both very low MBL levels (<100 μg/L; risk ratio (RR), 1.93; 95% CI, 1.14–3.28; __P__ = 0.014) and normal MBL levels (≥1,000 μg/L; RR, __P__ = 0.011) had significantly more frequent FN episodes than patients with low MBL levels (100–999 μg/L). Patients with very low MBL levels had significantly more episodes of FN with severe bacterial infection (bacteremia or pneumonia;
Who reads Serum Levels of Mannose-binding Lectin and the Risk of Fever in Neutropenia Pediatric Cancer Patients?
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- Author
- L.J. Schlapbach; C. Aebi; M. Otth; A. Ridolfi Luethy; K. Leibundgut; A. Hirt; R.A. Ammann
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)