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Tretinoin Reverses Upregulation of Matrix Metalloproteinase-13 in Human Keloid-derived Fibroblasts by Gentaro Uchida; Kotaro Yoshimura; Yukie Kitano; Mutsumi Okazaki; Kiyonori Harii is a Medicine article available to read on EtoBox.

What is Tretinoin Reverses Upregulation of Matrix Metalloproteinase-13 in Human Keloid-derived Fibroblasts about?

**Abstract** Keloids are skin abnormalities that are characterized by excessive deposition of collagen bundles in the dermis. Patients with keloids complain not only about their cosmetic appearance, but also about continuous itching and/or tenderness associated with chronic inflammation. Degradation of extracellular matrix (ECM) may be upregulated, associated with the expansion of keloids into circumferential skin, and high metabolic activity of keloid tissues may be due to increased matrix metalloproteinase (MMP) activity. Based on these hypotheses, we examined differences in expression of MMP‐1, MMP‐8, and MMP‐13 between keloid‐derived and normal dermal fibroblasts. Since retinoids are potent inhibitors of MMPs in the treatment of photoaged skin and cancers, we also examined whether or not tretinoin affects MMP expression of keloid‐derived fibroblasts. The results of real‐time polymerase chain reaction and ELISA demonstrated significant upregulation of MMP‐13 and significant downregulation of MMP‐1 and MMP‐8 in keloid‐derived fibroblasts, at both mRNA and protein levels. MMP‐1 mRNA expression in the control group was significantly upregulated after the addition of tretinoin, wher

Who reads Tretinoin Reverses Upregulation of Matrix Metalloproteinase-13 in Human Keloid-derived Fibroblasts?

Author

Gentaro Uchida; Kotaro Yoshimura; Yukie Kitano; Mutsumi Okazaki; Kiyonori Harii

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0906-6705)

Published

2003

Language

EN

Field

Medicine (Health Sciences)