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Curcumin and rheumatoid arthritis: A systematic review of literature by Fatemeh Pourhabibi‐Zarandi; Sara Shojaei‐Zarghani; Maryam Rafraf is a Medicine article available to read on EtoBox.

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## Background: Curcumin is a natural polyphenol and the main compound from the rhizome of turmeric (curcuma longa) and other curcuma species. it has been widely used for different medical purposes, such as improvement of pain and inflammatory conditions in various diseases. ## Purpose: This systematic review was aimed to assess all studies regarding the efficacy of the pure form of curcumin (unformulated curcumin) on rheumatoid arthritis (ra). ## Methods: The comprehensive search of the literature was done until september 2020 on the medline, embase, scopus and web of knowledge databases. out of 2079 initial records, 51 articles (13 in vitro and 37 animal and one human) were met our inclusion criteria. ## Results: Most studies have shown the curative effects of curcumin on clinical and inflammatory parameters of ra and reported different mechanisms; inhibition of mitogen-activated protein kinase family, extracellular signal-regulated protein kinase, activator protein-1 and nuclear factor kappa b are the main mechanisms associated with the anti-inflammatory function of curcumin in ra. the results of the only human study showed that curcumin significantly improved morning stiffness,

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Author

Fatemeh Pourhabibi‐Zarandi; Sara Shojaei‐Zarghani; Maryam Rafraf

Publisher

Hindawi Limited

Published

2021

Language

EN

Field

Medicine (Health Sciences)