About this Medicine article
Activated Immune System in Patients with Huntington's Disease by Friedrich Leblhuber; Johannes Walli; Kurt Jellinger; Gernot P Tilz; Bernhard Widner; Franco Laccone; Dietmar Fuchs is a Medicine article available to read on EtoBox.
## Abstract Abnormalities of immune system compartments were determined in 12 patients with Huntington's disease (eight males, four females; age 42.4 ± 11.7 years) and 11 controls (7 males, 4 females; age 47.0 ± 12.0). All patients were free from infectious diseases. Serum concentrations of a panel of serum soluble markers of immune activation were investigated, namely neopterin, 55-kDa-type soluble tumor necrosis factor receptor (sTNF-R), interleukin-2-receptor (sIL-2R), kynurenine, tryptophan, immunoglobulins (Ig) A, M and G as well as routine laboratory tests. Compared to controls, we found significantly higher serum levels of IgA (p < 0.01), sTNF-R, sIL-2R, neopterin, and complement component C3 (all p < 0.05), and serum tryptophan was decreased (p < 0.001). Higher concentrations of circulating immune complexes, cardiolipin antibodies, IgM, neopterin and lower tryptophan were associated with loss of cognitive function as assessed by the minimental-test. Five patients died within 1 year after measurements were performed. In these patients IgM, circulating immune complexes and neopterin concentrations were higher compared to survivors and serum tryptophan was lower. The data indi
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- Author
- Friedrich Leblhuber; Johannes Walli; Kurt Jellinger; Gernot P Tilz; Bernhard Widner; Franco Laccone; Dietmar Fuchs
- Publisher
- Walter de Gruyter GmbH
- Published
- 1998
- Language
- EN
- Field
- Medicine (Health Sciences)