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Structural Biology in Drug Discovery (Methods, Techniques, and Practices) by Renaud, Jean‐Paul is a scholarly article available to read on EtoBox.

What is Structural Biology in Drug Discovery (Methods, Techniques, and Practices) about?

"This book acts as a comprehensive guide about the principles, methods, and applications of structure-based drug discovery. It includes successful examples as well as recent developments in the field. Part 1 of the book covers necessary information and concepts of applying structural biology in the drug discovery process. It provides experimental and computational approaches to drug characterization and evaluation, an overview of fragment-based drug design, and a description of how to combine structural, thermodynamic and kinetic information for hit-to-lead drug development. Part 2 covers novel tools and techniques related to drug discovery, like automated platforms for protein characterization, various types of crystallizations, and high-throughput crystallography. Part 3 features case studies of structure-based discovery on important, established but still challenging therapeutic target families, as well as on monoclonal antibodies as an example of biotherapeutics. The final section illustrates new frontiers and challenges in the field, like intrinsically disordered proteins, neglected diseases, or viral resistance, and promising techniques for the future (XFELs and cryo-EM). Alt

Author

Renaud, Jean‐Paul

Publisher

Wiley & Sons, Limited, John

Published

2020

Language

EN

ISBN

9781118900505