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Can I read The role of CD4+CD25hi regulatory T cells in the physiopathogeny of graft-versus-host disease on EtoBox?
The role of CD4+CD25hi regulatory T cells in the physiopathogeny of graft-versus-host disease by José L Cohen; Olivier Boyer is a Immunology and Microbiology article available to read on EtoBox.
What is The role of CD4+CD25hi regulatory T cells in the physiopathogeny of graft-versus-host disease about?
Donor T cells present within hematopoietic stem cell transplants promote engraftment, contribute to T-cell reconstitution and provide an antileukemic effect. However, they are also responsible for the life-threatening graft-versushost disease. The subpopulation of CD4 + CD25 hi regulatory T cells, initially identified as crucial players in the regulation of autoimmune processes, might also play a role in the control of alloreactivity. Experimental studies in mice indicate that donor regulatory T cells indeed control alloreactive responses and reduce graft-versus-host disease. Recent clinical reports also suggest that higher numbers of CD4 + CD25 hi cells within the transplant or in the blood of grafted patients might be associated with reduced graft-versus-host disease. Hence, these cells are attractive immunoregulatory candidates to prevent graft-versus-host disease in humans.
Who reads The role of CD4+CD25hi regulatory T cells in the physiopathogeny of graft-versus-host disease?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- José L Cohen; Olivier Boyer
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0952-7915)
- Published
- 2006
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)