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Changes in Chromatin Proteins During Optic Nerve Regeneration in the Goldfish by J. M. Gossels; S. E. Lewis; N. I. Perrone-Bizzozero; Dr. L. I. Benowitz is a Neuroscience article available to read on EtoBox.

What is Changes in Chromatin Proteins During Optic Nerve Regeneration in the Goldfish about?

## Abstract Regeneration of the goldfish optic nerve involves massive changes in the structure and pattern of macromolecular synthesis in the retinal ganglion cells. To explore the mechanisms that underlie these events, we investigated the changes in chromatin proteins during the course of regeneration. Three major retinal chromatin proteins, two with apparent molecular weights of 58 kDa (C1 and C2) and one at 51 kDa (C3), all having isoelectric points around 5.5, showed a fourfold increase in their synthesis and/or accumulation by 14 days of regeneration. Synthesis of C1 and C3 decreased by day 32, the time at which the axons have grown back to the optic tectum and have formed many of their synapses; synthesis of C2 remained high through day 32. All three proteins bound to DNA‐cellulose and required high salt concentrations (0.2–0.5 M KCl) to be eluted. C1 and C2 had similar proteolytic digestion patterns and reacted with monoclonal antibodies that recognize the goldfish intermediate filament proteins of the ON complex. The proteins identified here could be involved in structural alterations in the chromatin, or might serve as transcription factors to regulate gene expression duri

Who reads Changes in Chromatin Proteins During Optic Nerve Regeneration in the Goldfish?

Author

J. M. Gossels; S. E. Lewis; N. I. Perrone-Bizzozero; Dr. L. I. Benowitz

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)

Published

1992

Language

EN

Field

Neuroscience (Life Sciences)