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Topically Administered Gold Nanoparticles Inhibit Experimental Corneal Neovascularization in Mice by Won-Kyung Cho; Seungbum Kang; Hyunsu Choi; Chang Rae Rho is a Medicine article available to read on EtoBox.

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## Purpose: The aim of this study was to evaluate the in vivo effects and mechanism of topically administered gold nanoparticles (aunp) in a mouse model of corneal neovascularization. ## Methods: Inflammatory corneal neovascularization was induced by alkali burns, and the corneas were treated with topical aunps. after 1 week, the area of corneal neovascularization was measured using image analysis. the levels of vascular endothelial growth factor receptor 2 and extracellular signal-regulated kinase (erk1/2) were evaluated by western blotting. ## Results: The area of corneal neovascularization was significantly reduced by 39.8% in the aunp group compared with the control group (p = 0.002). corneal vascular endothelial growth factor receptor 2 level was higher in the control group than in the aunp-treated group (p = 0.029). aunp treatment similarly inhibited burn-induced phosphorylation of erk (p = 0.029). ## Conclusions: Topical administration of aunps significantly reduced development of inflammatory corneal neovascularization by inhibiting the erk pathway.

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Author

Won-Kyung Cho; Seungbum Kang; Hyunsu Choi; Chang Rae Rho

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2015

Language

EN

Field

Medicine (Health Sciences)