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Immunoregulation in experimental murine Trypanosoma congolense infection: anti-IL-10 antibodies reverse trypanosome-mediated suppression of lymphocyte proliferation in vitro and moderately prolong the lifespan of genetically susceptible BALB/c mice by UZONNA; KAUSHIK; GORDON; TABEL is a Medicine article available to read on EtoBox.

What is Immunoregulation in experimental murine Trypanosoma congolense infection: anti-IL-10 antibodies reverse trypanosome-mediated suppression of lymphocyte proliferation in vitro and moderately prolong the lifespan of genetically susceptible BALB/c mice about?

__We infected highly susceptible BALB/c and relatively resistant C57BL/6 mice with cloned__ Trypanosoma congolense __and followed the effects of these infections on the circulating parasite numbers, mouse mortality and cytokine expression. C57BL/6 mice controlled their parasitaemia and survived for up to 163 ± 12 days, while BALB/c mice could not control their parasitaemia and succumbed to the infection within 8.4 ± 0.5 days. Susceptible BALB/c mice had dramatically higher plasma levels of IL‐10 than the resistant C57BL/6 mice from day 7 forward. This was preceded by an earlier and higher level induction of splenic IL‐10 messenger RNA (mRNA) expression in the infected BALB/c mice. There was a strong negative correlation between the splenocyte proliferative responses to Concanavalin‐A (Con‐A) and their production of IL‐10 in these infected BALB/c mice. Co‐treatment of the Con‐A‐stimulated spleen cell cultures with monoclonal anti‐IL‐10 antibodies, but not isotype‐matched control antibodies, could completely reverse this suppression of the splenocyte proliferative response. Finally, in three experiments, anti‐IL‐10 antibody treatment__ in vivo __reduced the peak circulating parasitae

Who reads Immunoregulation in experimental murine Trypanosoma congolense infection: anti-IL-10 antibodies reverse trypanosome-mediated suppression of lymphocyte proliferation in vitro and moderately prolong the lifespan of genetically susceptible BALB/c mice?

Author

UZONNA; KAUSHIK; GORDON; TABEL

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; FASEB (ISSN 0141-9838)

Published

1998

Language

EN

Field

Medicine (Health Sciences)