Opening book details…
Can I read Regional serotonin metabolism in the brain of transgenic mice lacking monoamine oxidase A on EtoBox?
Regional serotonin metabolism in the brain of transgenic mice lacking monoamine oxidase A by Nina K. Popova; Michael A. Gilinsky; Tamara G. Amstislavskaya; Ekaterina A. Morosova; Isabelle Seif; Edward De Maeyer is a Neuroscience article available to read on EtoBox.
What is Regional serotonin metabolism in the brain of transgenic mice lacking monoamine oxidase A about?
## Abstract The effect of a lack of the gene encoding monoamine oxidase A (MAO A) in transgenic Tg8 mice on the activity of tryptophan hydroxylase (TPH), the rate‐limiting enzyme in serotonin (5‐HT) biosynthesis, and on the levels of 5‐HT and 5‐hydroxyindoleacetic acid (5‐HIAA) in the midbrain, hypothalamus, hippocampus, striatum, amygdala, and frontal cortex was studied. It was shown that mice with a genetic MAO A knockout differed from mice of the initial C3H/HeJ strain in having a higher level of 5‐HT and a lower level of its metabolite, 5‐HIAA, in all brain regions but the frontal cortex, where the changes were insignificant. Although the 5‐HIAA/5‐HT ratio in various brain regions differed considerably, the decrease of the 5‐HT oxidative deamination index in Tg8 mice was similar in different brain regions (to 41–45% of control values), with the exception of the frontal cortex, where the decrease of the 5‐HIAA/5‐HT was somewhat smaller (to 54%). The presence of the remaining 45% ± 1.9% of the control ratio value indicates rather effective oxidative deamination of 5‐HT in MAO A knockout mice and explains the lack of severe behavioral and pathological consequences in MAO A genetic
Who reads Regional serotonin metabolism in the brain of transgenic mice lacking monoamine oxidase A?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Nina K. Popova; Michael A. Gilinsky; Tamara G. Amstislavskaya; Ekaterina A. Morosova; Isabelle Seif; Edward De Maeyer
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 2001
- Language
- EN
- Field
- Neuroscience (Life Sciences)