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What is SCFFBXO22 Regulates KDM4A Activity about?

The study identifies the SCFFBXO22 ubiquitin ligase complex as a regulator of histone demethylase KDM4A, which is responsible for the demethylation of histone H3 lysines 9 and 36. By targeting KDM4A for proteasomal degradation, SCFFBXO22 influences histone methylation levels and the transcription of the target gene ASCL2. This research highlights the role of FBXO22 in modulating chromatin marks and gene expression, suggesting implications for development and disease.

Author

cozaqu

Language

EN