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Sympathetic Control of Accommodation: Evidence for Inter-subject Variation by B. Gilmartin; E. A. H. Mallen; J. S. Wolffsohn is a Medicine article available to read on EtoBox.

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Autonomic innervation of ciliary smooth muscle is mediated principally by the parasympathetic nervous system and is supplemented by the sympathetic nervous system. Previous drug and nerve stimulation experiments on humans and animals have demonstrated that sympathetic innervation is inhibitory (via β‐2 adrenoceptors), relatively small, slow and augmented by concurrent levels of background parasympathetic activity. These characteristics are pertinent to the sympathetic system having a specific role in our ability to adapt successfully to sustained near vision tasks and, given the clear association between near vision and the onset and development of myopia, to a putative aetiological role in myopia development in pre‐disposed individuals. A fifth characteristic, namely the variation between individuals in access to an inhibitory sympathetic facility is therefore of particular interest. A novel method for continuous recording of accommodation, currently employed in a large sample longitudinal study of myopia in young adults, was used following topical instillation of non‐selective (timolol) and selective (betaxolol) sympathetic β‐adrenoceptor antagonists. Measures of post‐task accomm

Who reads Sympathetic Control of Accommodation: Evidence for Inter-subject Variation?

Author

B. Gilmartin; E. A. H. Mallen; J. S. Wolffsohn

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0275-5408)

Published

2002

Language

EN

Field

Medicine (Health Sciences)