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Can I read Polyphosphazene Nanodrugs for Targeting Delivery and Inflammation Responsive Release of Curcumin to Treat Acute Lung Injury by Effectively Inhibiting Cytokine Storms on EtoBox?
Polyphosphazene Nanodrugs for Targeting Delivery and Inflammation Responsive Release of Curcumin to Treat Acute Lung Injury by Effectively Inhibiting Cytokine Storms by Xiaochen Su; Xunan Jing; Wanting Jiang; Meng Li; Kai Liu; Menghao Teng; Yayun Ma; Daquan Wang; Lingjie Meng; Yingang Zhang; Wenchen Ji is a Materials Science article available to read on EtoBox.
What is Polyphosphazene Nanodrugs for Targeting Delivery and Inflammation Responsive Release of Curcumin to Treat Acute Lung Injury by Effectively Inhibiting Cytokine Storms about?
An excessive inflammatory response induced by cytokine storms is the primary reason for the deterioration of patients with acute lung injury (ALI). Though natural polyphenols such as curcumin (CUR) have antiinflammation activity for ALI treatment, they often have limited efficacy due to their poor solubility in water and oxidising tendency. This study investigates a highly cross-linked polyphosphazene nano-drug (PHCH) developed by copolymerisation of CUR and acid-sensitive units (4-hydroxy-benzoic acid (4-hydroxy-benzylidene)-hydrazide, D-HBD) with hexachlorotripolyphosphonitrile (HCCP) for improved treatment of ALI. PHCH can prolong the blood circulation time and targeted delivery into lung inflammation sites by enhancing CUR's water dispersion and anti-oxidant properties. PHCH also demonstrates the inflammation-responsive release of CUR in an inflammation environment due to the acid-responsive degradation of hydrazine bonds and triphosphonitrile rings in PHCH. Therefore, PHCH has a substantial anti-inflammation activity for ALI treatment by synergistically improving CUR's water-solubility, bioavailability and biocompatibility. As expected, PHCH attenuates the cytokine storm syndr
Who reads Polyphosphazene Nanodrugs for Targeting Delivery and Inflammation Responsive Release of Curcumin to Treat Acute Lung Injury by Effectively Inhibiting Cytokine Storms?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Xiaochen Su; Xunan Jing; Wanting Jiang; Meng Li; Kai Liu; Menghao Teng; Yayun Ma; Daquan Wang; Lingjie Meng; Yingang Zhang; Wenchen Ji
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Materials Science (Physical Sciences)