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The Evaluation of Surrogate Endpoints (Statistics for Biology and Health) by Geert Molenberghs, Marc Buyse, Tomasz Burzykowski (auth.), Tomasz Burzykowski, Geert Molenberghs, Marc Buyse (eds.) is a nonfiction available to read on EtoBox.

What is The Evaluation of Surrogate Endpoints (Statistics for Biology and Health) about?

Both humanitarian and commercial considerations have spurred intensive search for methods to reduce the time and cost required to develop new therapies. The identification and use of surrogate endpoints, i.e., measures that can replace or supplement other endpoints in evaluations of experimental treatments or other interventions, is a general strategy that has stimulated both enthusiasm and skepticism. Surrogate endpoints are useful when they can be measured earlier, more conveniently, or more frequently than the "true" endpoints of primary interest. Regulatory agencies around the globe, particularly in the United States, Europe, and Japan, are introducing provisions and policies relating to the use of surrogate endpoints in registration studies. But how can one establish the adequacy of a surrogate? What kind of evidence is needed, and what statistical methods portray that evidence most appropriately? This book offers a balanced account on this controversial topic. The text presents major developments of the last couple of decades, together with a unified, meta-analytic framework within which surrogates can be evaluated from several angles. Methodological development is coupled wi

Who reads The Evaluation of Surrogate Endpoints (Statistics for Biology and Health)?

Author

Geert Molenberghs, Marc Buyse, Tomasz Burzykowski (auth.), Tomasz Burzykowski, Geert Molenberghs, Marc Buyse (eds.)

Publisher

Springer-Verlag New York

Published

2005

Language

EN

ISBN

9781441919069

Category

nonfiction

Subjects

Mathematics, Science, Medical