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Determination of Binding Selectivities in Host-guest Complexation by Electrospray/quadrupole Ion Trap Mass Spectrometry by Sheryl M. Blair; Esther C. Kempen; Jennifer S. Brodbelt is a Chemistry article available to read on EtoBox.

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The quantifiable relationship between the equilibrium solution composition and electrospray (ESI) mass spectral peak intensities of simple host-guest complexes was investigated. Specifically, host-guest complexes of simple crown ethers or glymes with alkali metals and ammonium ions were studied. Comparisons were made between the theoretical concentrations of host-guest complexes derived in solution from known stability constants and the peak intensities for the complexes observed by ESI mass spectrometry (ESI-MS). Two types of complexation experiments were undertaken. First, complexation of a single guest ion, such as an alkali metal, and two crown ethers was studied to evaluate the determination of binding selectivities. Second, complexation of two different guest ions by a single polyether host was also examined. In general, solvation was found to play an integral part in the ability to quantify binding selectivities by ESI-MS. The more similar the solvation energies of the two complexes in the mixture, the more quantifiable their binding selectivities by ESI-MS. In some cases, excellent correlation was obtained between the theoretically predicted selectivity ratios and the ESI m

Who reads Determination of Binding Selectivities in Host-guest Complexation by Electrospray/quadrupole Ion Trap Mass Spectrometry?

Author

Sheryl M. Blair; Esther C. Kempen; Jennifer S. Brodbelt

Publisher

Elsevier Science; Springer-Verlag; Springer New York LLC; American Chemical Society (ACS); Springer Science and Business Media LLC; Elsevier BV (ISSN 1044-0305)

Published

1998

Language

EN

Field

Chemistry (Physical Sciences)