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Evaluation of an in Situ Setting Injectable Calcium Phosphate as a New Carrier Material for Gentamicin in the Treatment of Chronic Osteomyelitis: Studies in Vitro and in Vivo by U. Joosten; A. Joist; T. Frebel; B. Brandt; S. Diederichs; C. von Eiff is a Engineering article available to read on EtoBox.
What is Evaluation of an in Situ Setting Injectable Calcium Phosphate as a New Carrier Material for Gentamicin in the Treatment of Chronic Osteomyelitis: Studies in Vitro and in Vivo about?
A study was performed to investigate the effectiveness of hydroxyapatite cement (HAC) as a new carrier system in the treatment of chronic, posttraumatic osteomyelitis. In the in vitro study, release of gentamicin from standard cylinders of HAC were measured by agar diffusion test. As a representative for mechanical properties, compression strength was measured in order to detect changes when mixing HAC with gentamicin. In the in vivo study, bone infection was induced according to the model of Norden by injection of 1 ml Na-morrhuat and 3 x 10(6)CFU Staphylococcus aureus. After 3 weeks, when chronic stage of infection was obtained, 17 animals were treated by debridement and filling the marrow either with HAC alone or HAC mixed with gentamicin (32 mg/g). Animals of the control groups were left untreated. After 6 weeks, all animals were sacrificed. Hematological, radiological, microbiological and histological examinations were carried out by covered investigation. Best evidence of the efficiency of treatment was observed in histopathological and microbiological findings. In all swabs of the control groups, taken 6 weeks following infection S. aureus were detected which were clonal to
Who reads Evaluation of an in Situ Setting Injectable Calcium Phosphate as a New Carrier Material for Gentamicin in the Treatment of Chronic Osteomyelitis: Studies in Vitro and in Vivo?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- U. Joosten; A. Joist; T. Frebel; B. Brandt; S. Diederichs; C. von Eiff
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0142-9612)
- Published
- 2004
- Language
- EN
- Field
- Engineering (Physical Sciences)