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Quercetin Suppresses the Proliferation and Metastasis of Metastatic Osteosarcoma Cells by Inhibiting Parathyroid Hormone Receptor 1 by Shenglong Li; Yi Pei; Wei Wang; Fei Liu; Ke Zheng; Xiaojing Zhang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Quercetin Suppresses the Proliferation and Metastasis of Metastatic Osteosarcoma Cells by Inhibiting Parathyroid Hormone Receptor 1 about?

Osteosarcoma is an aggressive malignant neoplasm and cancerous bone tumor. Quercetin is a well-known flavonoid abundant in vegetables, fruits, grains, leaves, and red onions. In the present study, we evaluated the effects of quercetin-induced inhibition of parathyroid hormone receptor 1 (PTHR1) on proliferation, migration, and invasion in U2OS and Saos cells. Following incubation with quercetin (20, 40, 60, 80, or 100 μM) for 48 h, the cell viability of U2OS and Saos cells were significantly reduced in a dose-dependent manner. Additionally, there were significant decreases in cell adhesion, invasion, and migration as well as reduced cell viability at higher concentrations of quercetin. Furthermore, the mRNA expression levels of matrix metalloproteinases (MMP)-2 and -9 were attenuated, whereas the mRNA expression levels of tissue inhibitors of metalloproteinases (TIMP)-1 and -2 were elevated. Quercetin treatment also significantly reduced the mRNA expression levels of PTHR1 by 0.27-, and 0.55-fold at 80, and 100 μM, respectively, whereas 0.19 and 0.41 folds in Saos cells. PTHR1 protein expression in U2OS cells was reduced by 0.19-, and 0.43-fold at 80, and 100 μM of quercetin, respe

Who reads Quercetin Suppresses the Proliferation and Metastasis of Metastatic Osteosarcoma Cells by Inhibiting Parathyroid Hormone Receptor 1?

Author

Shenglong Li; Yi Pei; Wei Wang; Fei Liu; Ke Zheng; Xiaojing Zhang

Publisher

Elsevier Science; Elsevier ; Elsevier Masson; Elsevier BV (ISSN 0753-3322)

Published

2019

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)