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Dual amplification strategy turns TRPM2 channels into supersensitive central heat detectors by Ádám Bartók; László Csanády is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Significance Thermoregulation in the mammalian body is mediated by a central brain thermostat. Because deep-brain temperatures are maintained within a narrow range, the thermostat must contain a sensor that can differentiate temperature fluctuations as small as ±1°C around 37°C. No protein with such intrinsic properties is currently known. Recently, the ligand-gated ion channel TRPM2 was identified as pivotal for thermoregulation, but it is unclear whether the intrinsic properties of TRPM2 itself or temperature dependence of its agonist concentrations is responsible. Here, we show that the TRPM2 protein intrinsically possesses the unique properties essential for a deep brain temperature sensor: exceptional response-steepness and an optimal threshold. We uncover two unusual molecular mechanisms that serve to achieve that aim in a protein-autonomous manner.

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Author

Ádám Bartók; László Csanády

Publisher

Proceedings of the National Academy of Sciences

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)