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COVID-19 and risk of subsequent life-threatening secondary infections: a matched cohort study in UK Biobank by Can Hou; Yihan Hu; Huazhen Yang; Wenwen Chen; Yu Zeng; Zhiye Ying; Yao Hu; Yajing Sun; Yuanyuan Qu; Magnús Gottfreðsson; Unnur A. Valdimarsdóttir; Huan Song is a Medicine article available to read on EtoBox.
What is COVID-19 and risk of subsequent life-threatening secondary infections: a matched cohort study in UK Biobank about?
## Abstract ## Background With the increasing number of people infected with and recovered from coronavirus disease 2019 (COVID-19), the extent of major health consequences of COVID-19 is unclear, including risks of severe secondary infections. ## Methods Based on 445,845 UK Biobank participants registered in England, we conducted a matched cohort study where 5151 individuals with a positive test result or hospitalized with a diagnosis of COVID-19 were included in the exposed group. We then randomly selected up to 10 matched individuals without COVID-19 diagnosis for each exposed individual (n = 51,402). The life-threatening secondary infections were defined as diagnoses of severe secondary infections with high mortality rates (i.e., sepsis, endocarditis, and central nervous system infections) from the UK Biobank inpatient hospital data, or deaths from these infections from mortality data. The follow-up period was limited to 3 months after the initial COVID-19 diagnosis. Using a similar study design, we additionally constructed a matched cohort where exposed individuals were diagnosed with seasonal influenza from either inpatient hospital or primary care data between 2010 and 2019
Who reads COVID-19 and risk of subsequent life-threatening secondary infections: a matched cohort study in UK Biobank?
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- Author
- Can Hou; Yihan Hu; Huazhen Yang; Wenwen Chen; Yu Zeng; Zhiye Ying; Yao Hu; Yajing Sun; Yuanyuan Qu; Magnús Gottfreðsson; Unnur A. Valdimarsdóttir; Huan Song
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)