About this Medicine article

Immature Animals Have Higher Cellular Density in the Healing Anterior Cruciate Ligament Than Adolescent or Adult Animals by Ashley N. Mastrangelo; Brian M. Haus; Patrick Vavken; Matthew P. Palmer; Jason T. Machan; Martha M. Murray is a Medicine article available to read on EtoBox.

## Abstract There has been recent interest in the biologic stimulation of anterior cruciate ligament (ACL) healing. However, the effect of age on the ability of ligaments to heal has not yet been defined. In this study, we hypothesized that skeletal maturity would significantly affect the cellular and vascular repopulation rate of an ACL wound site. Skeletally Immature (open physes), Adolescent (closing physes), and Adult (closed physes) Yucatan minipigs underwent bilateral ACL transection and suture repair using a collagen‐platelet composite. The response to repair was evaluated histologically at 1, 2, and 4 weeks. All three groups of animals had completely populated the ACL wound site with fibroblasts at 1 week. The Immature animals had a higher cellular density in the wound site than the Adult animals at weeks 2 and 4. Cells in the Immature ligament wounds were larger and more ovoid than in the Adult wounds. There were no significant differences in the vascular density in the wound site. Animal age had a significant effect on the density of cells populating the ACL wound site. Whether this observed cellular difference has an effect on the later biomechanical function of the repa

Author

Ashley N. Mastrangelo; Brian M. Haus; Patrick Vavken; Matthew P. Palmer; Jason T. Machan; Martha M. Murray

Publisher

Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0736-0266)

Published

2010

Language

EN

Field

Medicine (Health Sciences)