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Does hypokalaemia cause nephropathy? an observational study of renal function in patients with Bartter or Gitelman syndrome by S. B. Walsh; E. Unwin; R. Vargas-Poussou; P. Houillier; R. Unwin is a Medicine article available to read on EtoBox.

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## Background: Hypokalaemic nephropathy has been described in patients with chronic potassium depletion; it is a condition in which proximal tubular vacuolization and interstitial fibrosis occur, resulting in a decline in glomerular filtration rate (gfr) and, in some cases, renal failure. it has been described in patients with chronic diarrhoea, eating disorders, laxative abuse and primary hyperaldosteronism; also occasionally in bartter syndrome (bs), in which severe hypokalaemia accompanies significant renal sodium and water losses, though rarely in gitelman syndrome (gs), in which there is equally severe hypokalaemia, but only modest sodium losses. ## Aim: We hypothesized that hypokalaemic nephropathy may not be due to potassium depletion per se, but persistently elevated circulating levels of aldosterone, possibly with superimposed episodes of renal hypoperfusion. ## Design and methods: We searched uk and european data sets to retrospectively compare serum and urinary parameters in patients with gs and bs. ## Results: The patients with gs often had lower serum potassium concentrations than patients with bs, but the bs patients had significantly higher serum creatinine concentra

Who reads Does hypokalaemia cause nephropathy? an observational study of renal function in patients with Bartter or Gitelman syndrome?

Author

S. B. Walsh; E. Unwin; R. Vargas-Poussou; P. Houillier; R. Unwin

Publisher

Oxford University Press (OUP)

Published

2011

Language

EN

Field

Medicine (Health Sciences)