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Serological evidence of chronic pulmonary Aspergillosis in tuberculosis patients in Kenya by Abdi Mohamed; Benear A. Obanda; Hannah K. Njeri; Sally N. Loroyokie; Olga M. Mashedi; Tom T. Ouko; Evangeline M. Gatumwa; Richard K. Korir; Takashi Yaguchi; Christine C. Bii is a Medicine article available to read on EtoBox.
What is Serological evidence of chronic pulmonary Aspergillosis in tuberculosis patients in Kenya about?
## Abstract ## Background Pulmonary tuberculosis (PTB) is a significant risk factor for fungal infection. The cavitary lesions post PTB serves as a good reservoir for fungal colonization and subsequent infection. Furthermore, the severe immunosuppression associated with HIV and TB co-infection is another predisposition. The inadequate capacity to investigate and manage fungal infection in PTB patients increases their morbidity and mortality. The study aimed to provide serological evidence of chronic pulmonary aspergillosis (CPA) among PTB patients in Kenya. Towards this, we analysed 234 serum samples from patients presenting with persistent clinical features of PTB infections despite TB treatment in four referral hospitals. ## Methods This was a cross sectional laboratory based study and patients were recruited following an informed consent. Serological detection of Aspergillus fumigatus IgG was done using enzyme-linked immunosorbent assay (Bordier Affinity Products SA). Sputum samples were subjected to microscopy and standard fungal culture. The isolated fungi were subjected to macro and micro morphological identifications and confirmed by sequence analysis of calmadulin, betatubi
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- Author
- Abdi Mohamed; Benear A. Obanda; Hannah K. Njeri; Sally N. Loroyokie; Olga M. Mashedi; Tom T. Ouko; Evangeline M. Gatumwa; Richard K. Korir; Takashi Yaguchi; Christine C. Bii
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)