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Extracellular Vesicles from Mesenchymal Stromal Cells for the Treatment of Inflammation-Related Conditions by Sean T. Ryan; Elham Hosseini-Beheshti; Dinara Afrose; Xianting Ding; Binbin Xia; Georges E. Grau; Christopher B. Little; Lana McClements; Jiao Jiao Li is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Extracellular Vesicles from Mesenchymal Stromal Cells for the Treatment of Inflammation-Related Conditions about?

Over the past two decades, mesenchymal stromal cells (MSCs) have demonstrated great potential in the treatment of inflammation-related conditions. Numerous early stage clinical trials have suggested that this treatment strategy has potential to lead to significant improvements in clinical outcomes. While promising, there remain substantial regulatory hurdles, safety concerns, and logistical issues that need to be addressed before cell-based treatments can have widespread clinical impact. These drawbacks, along with research aimed at elucidating the mechanisms by which MSCs exert their therapeutic effects, have inspired the development of extracellular vesicles (EVs) as anti-inflammatory therapeutic agents. The use of MSC-derived EVs for treating inflammation-related conditions has shown therapeutic potential in both in vitro and small animal studies. This review will explore the current research landscape pertaining to the use of MSC-derived EVs as anti-inflammatory and pro-regenerative agents in a range of inflammation-related conditions: osteoarthritis, rheumatoid arthritis, Alzheimer’s disease, cardiovascular disease, and preeclampsia. Along with this, the mechanisms by which MS

Who reads Extracellular Vesicles from Mesenchymal Stromal Cells for the Treatment of Inflammation-Related Conditions?

Author

Sean T. Ryan; Elham Hosseini-Beheshti; Dinara Afrose; Xianting Ding; Binbin Xia; Georges E. Grau; Christopher B. Little; Lana McClements; Jiao Jiao Li

Publisher

MDPI AG

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)