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A Drastic Shift in Lipid Adducts in Colon Cancer Detected by MALDI-IMS Exposes Alterations in Specific K^+^ Channels by Jone Garate; Albert Maimó-Barceló; Joan Bestard-Escalas; Roberto Fernández; Karim Pérez-Romero; Marco A. Martínez; Ma Antònia Payeras; Daniel H. Lopez; José Andrés Fernández; Gwendolyn Barceló-Coblijn is a Medicine article available to read on EtoBox.

What is A Drastic Shift in Lipid Adducts in Colon Cancer Detected by MALDI-IMS Exposes Alterations in Specific K^+^ Channels about?

## Simple Summary Colorectal cancer (CRC) is one of the most preventable yet deadliest cancers, one reason being that it involves very different lesions. Currently, there is a great international effort to improve CRC classification using as many molecular features as possible. A cutting-edge technique, imaging mass spectrometry, is used to enable the visualization of the bidimensional (2D) distribution of molecules across tissues in order to study how the composition of the cell membrane, in particular membrane lipids, changes in tumors. Our previous studies indicate that lipid composition is highly sensitive to cell alterations. Importantly, during the analysis, we are also able to establish changes in charged lipids, observations that can be misinterpreted. A close study of our results alongside information from public databases leads to the identification of gene coding for a potassium channel that could account for our observations and could represent a suitable target for drug development. ## Abstract Even though colorectal cancer (CRC) is one of the most preventable cancers, it is one of the deadliest, and recent data show that the incidence in people <50 years has unexpecte

Who reads A Drastic Shift in Lipid Adducts in Colon Cancer Detected by MALDI-IMS Exposes Alterations in Specific K^+^ Channels?

Author

Jone Garate; Albert Maimó-Barceló; Joan Bestard-Escalas; Roberto Fernández; Karim Pérez-Romero; Marco A. Martínez; Ma Antònia Payeras; Daniel H. Lopez; José Andrés Fernández; Gwendolyn Barceló-Coblijn

Publisher

MDPI AG

Published

2021

Language

EN

Field

Medicine (Health Sciences)