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Benefits of Renin-Angiotensin Blockade on Retinopathy in Type 1 Diabetes Vary With Glycemic Control by Tasma Harindhanavudhi; Michael Mauer; Ronald Klein; Bernard Zinman; Alan Sinaiko; M. Luiza Caramori; for the Renin Angiotensin System Study (RASS) group is a Medicine article available to read on EtoBox.
What is Benefits of Renin-Angiotensin Blockade on Retinopathy in Type 1 Diabetes Vary With Glycemic Control about?
## OBJECTIVE Optimal glycemic control slows diabetic retinopathy (DR) development and progression and is the standard of care for type 1 diabetes. However, these glycemic goals are difficult to achieve and sustain in clinical practice. The Renin Angiotensin System Study (RASS) showed that renin-angiotensin system (RAS) blockade can slow DR progression. In the current study, we evaluate whether glycemic control influenced the benefit of RAS blockade on DR progression in type 1 diabetic patients. ## RESEARCH DESIGN AND METHODS We used RASS data to analyze the relationships between two-steps or more DR progression and baseline glycemic levels in 223 normotensive, normoalbuminuric type 1 diabetic patients randomized to receive 5 years of enalapril or losartan compared with placebo. ## RESULTS A total of 147 of 223 patients (65.9%) had DR at baseline (47 of 74 patients [63.5%] in placebo and 100 of 149 patients [67.1%] in the combined treatment groups [__P__ = 0.67]). Patients with two-steps or more DR progression had higher baseline A1C than those without progression (9.4 vs. 8.2%, __P__ 7.5% had two-steps or more DR progression compared with 26 of 56 patients (46%) in the placebo gro
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- Author
- Tasma Harindhanavudhi; Michael Mauer; Ronald Klein; Bernard Zinman; Alan Sinaiko; M. Luiza Caramori; for the Renin Angiotensin System Study (RASS) group
- Publisher
- American Diabetes Association
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)