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Pair bonding and disruption impact lung transcriptome in monogamous Peromyscus californicus by A. Naderi; K. Liles; T. Burns; B. Chavez; K-T. Huynh-Dam; H. Kiaris is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Pair bonding and disruption impact lung transcriptome in monogamous Peromyscus californicus about?

Social interactions affect physiological and pathological processes, yet their direct impact in peripheral tissues remains elusive. Recently we showed that disruption of pair bonds in monogamous __Peromyscus californicus__ promotes lung tumorigenesis, pointing to a direct effect of bonding status in the periphery (Naderi et al., 2021). Here we show that lung transcriptomes of tumor-free __Peromyscus__ are altered in a manner that depends on pair bonding and superseding the impact of genetic relevance between siblings. Pathways affected involve response to hypoxia and heart development. These effects are consistent with the profile of the serum proteome of bonded and bond-disrupted __Peromyscus__ and were extended to lung cancer cells cultured in vitro, with sera from animals that differ in bonding experiences. In this setting, the species’ origin of serum (deer mouse vs FBS) is the most potent discriminator of RNA expression profiles, followed by bonding status. By analyzing the transcriptomes of lung cancer cells exposed to deer mouse sera, an expression signature was developed that discriminates cells according to the history of social interactions and possesses prognostic signif

Who reads Pair bonding and disruption impact lung transcriptome in monogamous Peromyscus californicus?

Author

A. Naderi; K. Liles; T. Burns; B. Chavez; K-T. Huynh-Dam; H. Kiaris

Publisher

BioMed Central

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)