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Can I read Analysis of Hand Joint Space Morphology in Women and Men with Hereditary Hemochromatosis on EtoBox?
Analysis of Hand Joint Space Morphology in Women and Men with Hereditary Hemochromatosis by Ursula Heilmeier; Andrew J. Burghardt; Justin J. Tse; Puneet Kapoor; Kathryn S. Stok; Sarah Manske; Reinhard E. Voll; Georg Schett; Stephanie Finzel is a Medicine article available to read on EtoBox.
What is Analysis of Hand Joint Space Morphology in Women and Men with Hereditary Hemochromatosis about?
Hereditary hemochromatosis (HH) causes unbalanced iron deposition in many organs including the joints leading to severe cartilage loss and bone damage in the metacarpophalangeal joints (MCPJ). High-resolution peripheral quantitative computed tomography (HR-pQCT) and its joint space width (JSW) quantification algorithm quantifies __in vivo__ 3D joint morphology. We therefore aimed to (i) determine feasibility and performance of the JSW algorithm in HH, (ii) quantify joint space morphology, and (iii) investigate the relationship between morphological and clinical parameters in HH. Here, we performed an exploratory study on 24 HH patients and sex- and age-matched controls using HR-pQCT imaging of MCPJ. Mineralized bone structure was automatically segmented from the grayscale image data and periosteal surface bone masks and joint space masks were generated. Mean, minimal, and maximal joint space width (JSW; JSW.MIN; JSW.MAX), JSW heterogeneity (JSW.SD), JSW asymmetry (JSW.AS), and joint space volume (JSV) were computed. Demographics and, for HH patients, disease-specific parameters were recorded. Segmentation of JS was very good with 79.7% of MCPJs successfully segmented at first attem
Who reads Analysis of Hand Joint Space Morphology in Women and Men with Hereditary Hemochromatosis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ursula Heilmeier; Andrew J. Burghardt; Justin J. Tse; Puneet Kapoor; Kathryn S. Stok; Sarah Manske; Reinhard E. Voll; Georg Schett; Stephanie Finzel
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)