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Developmental programming of appetite and growth in male rats increases hypothalamic serotonin (5-HT)5A receptor expression and sensitivity by Edward T. Wargent; Malgorzata S. Martin-Gronert; Roselle L. Cripps; Lora K. Heisler; Giles S. H. Yeo; Susan E. Ozanne; Jonathan R. S. Arch; Claire J. Stocker is a Medicine article available to read on EtoBox.
What is Developmental programming of appetite and growth in male rats increases hypothalamic serotonin (5-HT)5A receptor expression and sensitivity about?
## Background: Though it is well established that neonatal nutrition plays a major role in lifelong offspring health, the mechanisms underpinning this have not been well defined. early postnatal accelerated growth resulting from maternal nutritional status is associated with increased appetite and body weight. likewise, slow growth correlates with decreased appetite and body weight. food consumption and food-seeking behaviour are directly modulated by central serotonergic (5-hydroxytryptamine, 5-ht) pathways. this study examined the effect of a rat maternal postnatal low protein (plp) diet on 5-ht receptor mediated food intake in offspring. ## Methods: Microarray analyses, in situ hybridization or laser capture microdissection of the arc followed by rt-pcr were used to identify genes up- or down-regulated in the arcuate nucleus of the hypothalamus (arc) of 3-month-old male plp rats. third ventricle cannulation was used to identify altered sensitivity to serotonin receptor agonists and antagonists with respect to food intake. ## Results: Male plp offspring consumed less food and had lower growth rates up to 3 months of age compared with control offspring from dams fed a normal diet.
Who reads Developmental programming of appetite and growth in male rats increases hypothalamic serotonin (5-HT)5A receptor expression and sensitivity?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Edward T. Wargent; Malgorzata S. Martin-Gronert; Roselle L. Cripps; Lora K. Heisler; Giles S. H. Yeo; Susan E. Ozanne; Jonathan R. S. Arch; Claire J. Stocker
- Publisher
- Springer Science and Business Media LLC
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)