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Characterization of the neutralizing anti‐emicizumab antibody in a patient with hemophilia A and inhibitor by Carla Valsecchi; Marco Gobbi; Marten Beeg; Ty Adams; Giancarlo Castaman; Lucia Schiavone; James A. Huntington; Flora Peyvandi is a Medicine article available to read on EtoBox.
What is Characterization of the neutralizing anti‐emicizumab antibody in a patient with hemophilia A and inhibitor about?
## Background: The genetically engineered, humanized, bispecific monoclonal antibody emicizumab (hemlibra) that mimics the cofactor activity of activated factor viii (fviii) has been approved for treatment of hemophilia a patients with and without inhibitor. in the pivotal premarketing clinical trials, emicizumab prophylaxis significantly reduced bleeding rates compared with previous treatments and was well tolerated. however, a consequence of this novel therapy may be the host immune response to a foreign protein. ## Objective: Characterization of the neutralizing anti-emicizumab antibody associated with the loss of treatment efficacy. ## Patient: A pediatric hemophilia a patient with inhibitor enrolled in the haven2 (study of emicizumab administered subcutaneously (sc) in pediatric participants with hemophilia a and factor viii (fviii) inhibitors) clinical trial. ## Methods: The anti-emicizumab antibody has been characterized with western blot and enzyme-linked immunosorbent assay (elisa). the antibody was affinity purified and sequenced. binding affinity to full-length and papain-digested emicizumab was analyzed using surface plasmon resonance and byo-layer interferometry. ## Re
Who reads Characterization of the neutralizing anti‐emicizumab antibody in a patient with hemophilia A and inhibitor?
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- Author
- Carla Valsecchi; Marco Gobbi; Marten Beeg; Ty Adams; Giancarlo Castaman; Lucia Schiavone; James A. Huntington; Flora Peyvandi
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)