Can I read Adenoviral-mediated gene transfer of Gadd45a results in suppression by inducing apoptosis and cell cycle arrest in pancreatic cancer cell on EtoBox?

Adenoviral-mediated gene transfer of Gadd45a results in suppression by inducing apoptosis and cell cycle arrest in pancreatic cancer cell by Yunfeng Li; Haili Qian; Xiao Li; Haijuan Wang; Jing Yu; Yongjun Liu; Xueyan Zhang; Xiao Liang; Ming Fu; Qimin Zhan; Chen Lin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Adenoviral-mediated gene transfer of Gadd45a results in suppression by inducing apoptosis and cell cycle arrest in pancreatic cancer cell about?

## Abstract ## Background The extremely poor prognosis of patients with pancreatic ductal adenocarcinoma indicates the need for novel therapeutic approaches. The growth arrest and DNA damage‐inducible (Gadd) gene __Gadd45a__ is a member of a group of genes that are induced by DNA damaging agents and growth arrest signals. ## Methods We evaluated the biological activity of Gadd45a in pancreatic ductal adenocarcinoma cancer‐derived cell lines and assessed the efficacy of a combined treatment with adenoviral‐mediated expression of Gadd45a (Ad‐G45a) and anticancer drug (Etoposide, cisplatin, 5‐fluorouracil, respectively) for the PANC1 cell line. ## Results Gadd45a is variously expressed in cell lines derived from pancreatic ductal adenocarcinoma cancer and adenoviral‐mediated expression of Gadd45a (Ad‐G45a) in these cells results in apoptosis via caspase activation and cell‐cycle arrest in the G2/M phase. Gadd45a significantly increased the chemosensitivity of PANC1, which may be due to abundant apoptosis induction and cell cycle arrest. By combinational treatment of Ad‐G45a infection and chemotherapeutics, Gadd45a expression was elevated to a higher extent in cancer cells with wild‐ty

Who reads Adenoviral-mediated gene transfer of Gadd45a results in suppression by inducing apoptosis and cell cycle arrest in pancreatic cancer cell?

Author

Yunfeng Li; Haili Qian; Xiao Li; Haijuan Wang; Jing Yu; Yongjun Liu; Xueyan Zhang; Xiao Liang; Ming Fu; Qimin Zhan; Chen Lin

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1099-498X)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)