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Japs 2014 by nguyenthikieuanht67 is a document available to read on EtoBox.
This study focuses on the design, synthesis, and cytotoxic evaluation of new thiopyrimidine-5-carbonitrile derivatives against the HepG2 cell line. Among the synthesized compounds, 4a demonstrated the highest potency with an IC50 value of 13.18 µM, significantly lower than that of the reference drug 5-FU. Additionally, molecular docking studies were conducted to explore the binding interactions of these compounds with thymidylate synthase, a key enzyme in DNA synthesis.
- Author
- nguyenthikieuanht67
- Language
- EN